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Gordon, I

July 23, 2008

It is not FDA-approved for general therapeutic use in humans, and the World Anti-Doping Agency added it to its Prohibited List in 2022

Because its activity centers on angiogenesis modulation, study designs in oncology-adjacent contexts typically account for this mechanism

Notably, individuals with more advanced liver disease exhibited the highest endogenous BAC, and BAC could be manipulated to increase or decrease by pre-treating patients with an infusion of an inhibitor of hepatic alcohol metabolism (4-methylpyrazole) or with a course of broad-spectrum antibiotics, respectively (63)