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In their function as RanGAPs, plexins may facilitate the direct regulation of the Ran system by extracellular cues at the plasma membrane, thereby serving a function distinct from that of RanGAP1

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P63 and P73 activation in cancers with p53 mutation

Genome studies in Brassica [202] maize, tomato, and Arabidopsis also indicated the presence of PP2C gene families, responsible for abiotic stress tolerance [203, 204]

Studies were excluded if they were duplicative, lacked sufficient data, were of limited relevance, or focused on non-diabetic renal diseases without metabolic assessment

The therapeutic mechanism includes the reactivation of hormonal signaling pathways, demonstrated by significantly elevated plasma E2 levels in treated mice over time