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The specific mechanisms underlying these differences remain unclear, though they may involve factors such as thrombin signaling or variations in smoking behavior between genders

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In contrast, a significant number of CpG sites can be studied with EWASs 24,25,26

Even among patients with intracranial stenosis ( Case 2-1 ), a condition that may be associated with cerebral hypoperfusion, elevated BP in the postacute phase was associated with recurrent stroke.8 In the recent Secondary Prevention of Small Subcortical Strokes (SPS3) trial, a lower systolic BP target (less than 130 mm Hg) was associated with a decrease in recurrent stroke (hazard ratio [HR] 0.81, P =.08) with a significant reduction in hemorrhagic stroke events in patients with lacunar stroke (HR 0.37, P =.03).9 However, a recent post hoc analysis of the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial found that very low systolic BP (less than 120 mm Hg) after recent stroke was associated with increased risk of recurrent stroke compared with those with normal BP defined as 120 to 139 mm Hg.10 These data suggest that a goal BP of approximately 120 to 140 mm Hg (systolic) and 80 to 90 mm Hg (diastolic) may be ideal

DOI Parliament of the Commonwealth of Australia

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