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It is foundational to cellular health, and its depletion is a consistent feature of chronic disease, aging, oxidative stress, and toxic burden

Mariner mutants exhibit reduced damage to aminoglycoside or cisplatin ototoxicity because these drugs rely on functional mechanotransduction for uptake (Wang and Steyger, 2009

Arch Biochem Biophys 433:166175 Banerjee R, Zou CG (2005) Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein

Bevacizumab, an anti-VEGF therapy, has been shown to enhance the effects of radiation and chemotherapy, though its ability to extend survival has been limited [58]