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These probabilities matter when you are deciding which medication to try first, because time spent on a less effective option is time without the metabolic benefits a more effective option might provide

While early oral versions were less effective, largely due to poor absorption from the gut, we now have new oral formulations with improved absorption and adjusted dosing so you can see greater results without needing injections

General Section, 98 (1), 1-13

Progressive overload strengthens connective tissue and restores joint stability

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The mismatch isn't fatal to results, but it's suboptimal