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Longer regimens remain viable for patients with additional resistance, intolerance to short-course drugs, severe disease, pregnancy, certain extrapulmonary TB cases, or other complex needs, with alternative agents recommended as needed (i.e., streptomycin, levofloxacin, clofazimine, and delamanid) (Vanino et al., 2023)

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50 In addition to the bacterial genomic mutations, plasmid-mediated mechanisms play an important role in the generation of quinolone resistance

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10 , e2207170 (2023)