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doi: 10.1002/hep.24690

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As the first polyamine molecule synthesized de novo in mammals, the formation of putrescine is mediated by ODC, one of the key rate-limiting enzymes for polyamine synthesis, which is regulated by various genes, such as increased levels of ARG1 and ornithine aminotransferase (OAT) and decreased levels of ODC antizyme (OAZ) and spermidine/spermine-N1-acetyltransferase (SAT1) [274]

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295 Honeysuckle-Cassia seed extract, after co-fermentation, had increased bioactive component content in its mixed bacterial fermentation broth and improved liver injury, oxidative stress, and gut flora dysbiosis in a mouse ALD model