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Other systemic toxicity A meta-analysis of four in vivo studies conducted by PMI researchers assessed the impact of IQOS on the activity of the cytochrome P450 1 A2 (CYP1A2) enzyme responsible for the metabolism of harmful xenobiotics like amines

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doi: 10.2105/ajph.86.11.1582, Summary Keywords agent-based modeling, mortality estimates, nicotine pouches, oral tobacco-derived nicotine, population health, three-product population modeling Citation Muhammad-Kah R, Hannel T, Wei L, Cheng H, Iyer S and Sarkar M (2026) Investigating the population health impact of an oral tobaccoderived nicotine pouch product utilizing a three-product tobacco use population model