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Chin J Nat Med [Internet]

This discrepancy might be explained by different determination protocols/assays applied among the studies

Reactive nitrogen species Cells initiate the synthesis of reactive nitrogen species (RNS) and generate ROS via the interaction of oxygen with the nitric oxide radical (NO)

Acyltransferases mediating butyrylation exhibited distinct substrate specificities: in vitro studies demonstrated that CBP/p300 (CREB-binding protein/E1A binding protein p300) directly butyrylates both histone H4 and non-histone protein p53 [58], whereas Gcn5 mutation significantly reduced histone H3 butyrylation [60]