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Reconstitution should be performed using appropriate laboratory-grade diluents under controlled conditions to maintain peptide integrity and consistency throughout handling

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13 Symptoms are usually symmetrical and distal, including paresthesia, cramps, weakness, and pain

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The imidazole nitrogen of the histidine side chain donates one of the three nitrogen ligands to the copper, and the position of histidine at the second residue is what enables the deprotonated amide nitrogen of the preceding Gly-His peptide bond to also coordinate the copper

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