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Animal models attempting to replicate the dopaminergic pathology and clinical features of PD have been critical to our understanding of the pathogenic mechanisms of the disease

This is a stark contrast to the typically slow improvement of polyneuropathy in POEMS, and could imply that at least part of the underlying mechanism causing neuropathy in POEMS may be related to vitamin B6 deficiency, and that an evaluation of vitamin levels in POEMS may be currently underappreciated

63, 680686 [PMC free article] [PubMed] [Google Scholar] Willekens F

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In humans and many other animals, they serve to break down alcohols that are otherwise toxic, and they also participate in the generation of useful aldehyde, ketone, or alcohol groups during the biosynthesis of various metabolites