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Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder

N.CostaV.BaloyannisS

Oxidative stress appears to upregulate and enhance the activity of inducible nitric oxide synthase (iNOS) that is accompanied by the overproduction of large amounts of NO that together with superoxide anion may produce, through already mentioned metal catalyzed Haber-Weiss reaction, the peroxynitrites, potent damaging factors for the cell structure (34)