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Genetic variants in B12 metabolism pathways (e.g., MTHFR, MTR, MTRR genes) can influence how efficiently your body processes and utilizes B12, potentially affecting both side-effect risk and clinical benefit

borderline results may require additional testing of methylmalonic acid (MMA) and/or homocysteine levels for confirmation

[DOI] [PubMed] [Google Scholar] 39.Cruciani R.A., Dvorkin E., Homel P., Culliney B., Malamud S., Fleishman S., Lapin J., Lesage P., Portenoy R., Cruciani-Esteban N.V

B12 may lower homocysteine levels which could contribute to a lower odds of heart disease, but only in people who have a diagnosed B12 deficiency, Swenor says

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Always consult with a healthcare professional before starting any new weight loss treatment to ensure it is appropriate for your individual needs and health conditions