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Larger particles tend to deposit in the lower segmental bronchi and larger airways, while smaller particles penetrate deeper, reaching the small airways and alveoli, contributing to chronic inflammation, airway remodeling, and carcinogenesis. Editorial Comment: The dual nature of cigarette toxinsfloating gaseous irritants and falling particulate carcinogensexplains their widespread destructive impact on the respiratory system.Ashley Davidoff, MDTheCommonVein.comLungs-0790Upper and Lower Lung Field Distribution of Smoking-Related Lung DiseasesCigarette smoke contains approximately 7,000 toxins, of which 70 are carcinogenic

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Dozens of studies have also shown damage at the cellular level

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