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We previously showed the presence of mitochondrial dysfunction as early as P15 in the motor cortex, but more precisely in the CSMN of TDP-43 A315T mice 17 , one of the best characterized mouse models of TDP-43 pathology 16,19,33,34

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Nevertheless, revealing the underlying mechanism of Nrf2 agonists or HO-1 inhibitors in the treatment of PF warrants further investigation

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Thyroid malfunction is prevalent across the globe, and it is identified as a controllable and treatable disease

No evidence of a heme group was found as illustrated by the absence of Soret band at 430 nm in the absorption profile