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Off-label and investigational drugs in the treatment of alcohol use disorder: A critical review

"I haven't given up

Alicia Zellmer, MD, and Joy Liu, MD, are resident physicians in internal medicine and members of the ABC News Medical Unit.

Hydrochlorothiazide Hydrochlorothiazide had no adverse effects on the fertility of mice and rats of either sex in studies wherein these species were exposed, via their diet, to doses of up to 100 and 4 mg/kg/day, respectively, prior to mating and throughout gestation

Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)

Patients should inform their healthcare provider of all medications and supplements they are taking to minimize the risk of adverse interactions, and healthcare professionals should evaluate each regimen prior to initiating glutathione therapy