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J Clin Invest (2022) 132(9):e152345

A.WilliamT.et al (2018)

Our study strongly indicates that abrupt caffeine withdrawal in patients with migraine actually triggers migraine

The development of DNA methylation-based epigenetic clocks that reflect aging, when combined with disease-specific DNA methylation alterations, holds promise for identifying biomarkers and predicting disease risk (Horvath and Raj, 2018