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Further, GR is inhibited by an excess concentration of GSH, and by a rise in the NADP + :NADPH/H + ratio [12, 13, 52] (Fig

2018, 2018, p

Biomed Pharmacother 137:111369 Silke J, OReilly LA (2021) NF-B and pancreatic cancer

Fe + drives the Fenton reaction, producing unstable hydroxyl radicals that initiate lipid oxidation of PUFAs, forming conjugated dienes and eventually yielding toxic lipid peroxidation products such as 4-hydroxynonenal (4-HNE) and MDA