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Iron overload As a common trace element, iron is distributed in the liver, spleen and bone marrow of the human body, which is closely related to the hematopoietic function of body and is necessary to maintain the normal life activities of human [22, 23]

Its the backup the system is designed to use when needed, as eClinpath notes

Reddy et al., 2023

Activated Nrf2 was firstly found to inhibit ferroptosis by regulating the expression of NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1) and FTH1 in hepatocellular carcinoma[50]

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