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118,119 Chronic inflammation, a hallmark of metabolic disorders, is also influenced by E3 ligases

4.4.3 Ursolic Acid Ursolic acid is a compound extracted from plants such as rosemary and fruit peels (Seo et al., 2018)

Mutations in the CBS gene also increase Hcy levels by affecting cystathionine conversion

It was first described and also named in 1921 (Hopkins) and in 1935 it could be synthesized and its structure was definitively established

This comprehensive search utilized databases such as PubMed, Scopus, and Web of Science, with keywords including ME/CFS, Gut-Brain Axis, Gut Health, Intestinal Dysbiosis, Microbiome Dysbiosis, Pathophysiology, and Therapeutic Approaches. Where possible, insights from clinical trials and observational studies were included to enrich the findings