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The compound operates through a unique triple mechanism: inhibiting the reuptake of norepinephrine (NET), dopamine (DAT), and serotonin (SERT) transporters with IC50 values of 1.7 nM, 65 nM, and 11 nM respectively

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Always use a new, sterile needle for each injection and dispose of used needles properly in a designated sharps container

Importantly, phenotypic plasticity is not just a phenomenon in adults, but rather includes cases of fixed, irreversible, and distinct developmental trajectories that may or may not culminate in altered adult phenotype (Kelly et al., 2012

Overall, patient populations studied in IKEMA and CANDOR were quite similar, with a median of 2 prior treatment lines and similar refractoriness to lenalidomide (33 vs

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