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The upregulation of DC numbers in individuals exposed to cigarette smoke likely resulted from a rise in the cell survival, which was supported by a previous study on the responsiveness of human and murine DCs to smoke exposure [109]

Discussion Cigarettes are known to be highly toxic and can exert multiple effects on the pulmonary system, including, but not limited to, increases in apoptosis, inflammation, protease activation, DNA breaks as well as deranging the mucus clearance system 6

This makes it easier to rely on, especially for long-term use

Leaks can also happen because of cabin pressure changes during flights, so travellers are advised to seal e-liquid bottles carefully

The tobacco industry pinpointed and exploited these factors to its advantage

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