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doi: 10.1016/j.neuropharm.2019.107682 20

and the modulation of metabolic genes is consistent with the accumulation of osmotic protectants, including TPS, and antioxidants like TFC

Borda, L

Pharmacology Biochemistry and Behavior, 13 , 53-61

In cellular models using mouse brain endothelial cells as well as in vivo studies, it was shown that OC administration increased the brain efflux index of I-A40 in C57BL/6 wild-type mice from 62.0 3.0% to 79.9 1.6% (80, 81)