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Mechanistically, inhibition of the PI3K/AKT/mTOR axis resulted in increased expression of pro-apoptotic proteins caspase-3, caspase-9, and Bax, while reducing the expression of the anti-apoptotic protein Bcl-2, thereby accelerating apoptotic events in LCSCs

Uric acid stimulates hepatic steatosis either directly or by activating NLRP3 inflammasomes

2015 (5) CD010012

Although these treatments often cause leaching of polyphenols into cooking water, they are also effective at reducing anti-nutrients that bind dietary phenolics (Abbas & Ahmad, 2018

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

P., Kautz, M