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Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure

Oxidative damage, mitochondrial malfunction, glutamate excitotoxicity, inflammatory reaction, protein accumulation and modification in metal ion homeostasis are the principal factors leading to CNS disorders (Chen et al., 2005

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Under a non-monotonic curve, an increase producing less effect is ambiguous: it cannot distinguish being below the peak from having passed it

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