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stabilizing agents

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Clinical data shows benefits fade within 2-6 months despite maintenance therapy, with only 6.2% of patients retaining any effect at 6 months in the Zubair et al

Concurrently, mitochondrial dysfunction leads to ROS accumulation, exacerbating oxidative stress damage (Yasuda et al., 2021)

Nutrient Deficiencies (Building Blocks Missing) Glutathione synthesis requires specific nutrients: Cysteine : From dietary protein (whey, eggs, poultry)-rate-limiting Glycine : Often deficient in modern diets (need 10-15g/day, most get 3-5g) Selenium : Cofactor for glutathione peroxidase (GPx) , the enzyme that recycles GSSG back to GSH B vitamins (B6, B9, B12): Required for methylation and sulfur metabolism Vitamin C : Recycles oxidized glutathione Deficiency in any of these impairs glutathione production or recycling [5]