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Clinical findings often depend on the substance abused, the frequency of use, and the length of time since last used, and may include: Weight loss Constant fatigue Red eyes Little concern for hygiene Lab abnormalities Unexpected abnormalities in heart rate or blood pressure Depression, anxiety, or sleep problems Treatment for substance abuse or dependence: Specific treatment for substance abuse or dependence will be determined by your doctor based on: Your age, overall health, and health history Extent of the symptoms Extent of the dependence Type of substance abused Your tolerance for specific medicines, procedures, or therapies Expectations for the course of the condition Your opinion or preference A variety of treatment (or recovery) programs for substance abuse are available on an inpatient or outpatient basis

On November 1, 2023 , the American Cancer Society released new guidelines for lung cancer screening

(accessed July 25, 2026)

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Stimulant stacking: Mixing in caffeine or energy drinks doubles down on the adrenaline surge