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The versatility of PLGA allowed for its use in other sustained-release products, including Risperdal Consta, approved in the early 2000s for schizophrenia treatment 115

Its human data stop at GH/IGF-1 surrogate markers

225,226,227,228 Backbone modification The modification strategies used in first-generation NADs have focused on modification of the phosphate backbone, mainly using other types of groups to replace the non-bridging oxygen atoms in the phosphate backbone, such as phosphorothioate (PS), methyl phosphate, and boranophosphate

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The findings in our main cohort were also validated in a second independent set of patients

Esposito 2010