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Thereby, protein-binding interactions are unlikely to be clinically relevant ( Digital tools highlight that potential DDIs between bupropion and antidiabetics (namely glimepiride, glipizide, glyburide, gliclazide, metformin, sitagliptin, linagliptin, saxagliptin, and canagliflozin) may occur

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Addressing these gaps through rigorous future studies (e.g., well-controlled longitudinal cohorts, clinical trials, and mechanistic experiments adapted for adolescent participants) will be essential to draw more definitive conclusions and inform evidence-based public health guidance for youth vaping

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