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Mitochondria, as the primary source of ROS in mammalian cells, are particularly vulnerable, with oxidative stress contributing to mitochondrial dysfunction, energy depletion, and cell death (Cui et al., Several studies have highlighted oxidative stress as a key factor in ME/CFS

L-Carnitine is shown to have a beneficial impact on weight loss, exercise performance, reduction in muscle soreness, and increased oxygen supply to muscles

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Note: Glutathione is a compounded prescription medication, not FDA-approved

The present review also high-lighted the potential of low-iron diets and lifestyle changes as preventive measures against ferroptosis-related CVDs