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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimers disease

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the GSMR method was implemented in the GCTA (Genome-wide Complex Trait Analysis) software ( Reported results and interpretation of findings MR IVW odds ratios (OR) with 95% CI, per unit increase in the exposures (e.g., per unit increase of log-transformed alcoholic drinks per week or lifetime smoking index), with P -values derived from two-sided tests, corrected for outlier or invalid variants, are presented in Tables 15

This approach is based on a relatively simple concept: while tobacco addiction is due to nicotine, it is rather the tobacco combustion products present in cigarette smoke that are responsible for smoking-related health problems