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The NLRP3 inflammasome is also activated by mtDNA and mtROS, further contributing to neuroinflammatory cascades [223]

1.1 ENS serves as the primary regulator of intestinal motility and secretory function ENS functions as the central integrative regulator of gastrointestinal motility and secretory activity, coordinating complex sensorimotor programs through a highly specialized neuromodulatory network

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Thus, arginase 1 inhibitors can exert a double-strike, promoting antitumor immunity and dysregulating important metabolic pathways for tumor and CAFs cells biology/function

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