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The parameters below describe how it is used in supervised clinical care they are not a recommendation to self-administer, and we do not publish dosing for unsupervised use

Using glycine as an example, with a carboxyl group p K a of 2.34 and 9.60 as the p K a of its protonated amino group, we can calculate the equilibrium constant for the proton transfer reaction: 1 H 2 NCH 2 COOH H + + H 2 NCH 2 COO 2 H + + H 2 NCH 2 COO + H 3 NCH 2 COO sum : H 2 NCH 2 COOH + H 3 NCH 2 COO The equilibrium constant for such a proton transfer reaction is calculated as follows (with the subscript 1 denoting the carboxyl group and 2 denoting the amino group): p K eq = p K a1 p K a2 = 2.34 9.60 = 7.26 K eq = 10 p = 10 K eq +7.26 = 1.8 10 7 This equilibrium greatly favors the zwitterion

Studies have also shown that the clinical outcomes may differ among various CDR devices, requiring surgeons to tailor the device choice to specific patient profiles (Wahood et al., 2020)