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While it is too early to say whether or to what extent e-cigarettes can be used to support smoking cessation, one conclusion can already be drawn: Vaping is not without health effects.

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Second, pretreatment with nicotine does not fully capture the myriad of other psychoactive constituents that are present in tobacco leaves, combustible tobacco products, or e-cigarette vaping liquids, and further investigations are needed in order to characterize how these other psychoactive constituents interact with nicotine and fluoxetine

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