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In the case of tobacco smoking, these active substances are a mixture of aerosol particles that include the pharmacologically active alkaloid nicotine, which stimulates the nicotinic acetylcholine receptors in the brain, and other non-psychoactive chemicals that result from combustion

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They require less physical 'pocket space' when fewer cigarettes remain in the pack

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(The high barrier to entry is part of why there are currently no FDA-approved e-cigarettes on the market.) The FDA itself has predicted that the eventual costs of compliance for e-cigarettes will be high enough to expect additional product exit, consolidation, and reduction in variety. The agency didnt even release final guidance on what to include in applications until this past June