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2022 Apr 5;2022:8192552

Notably, research pertaining to HUA and its ensuing complications has predominantly focused on neutrophils

Following membrane damage, the activation of voltage-gated Ca 2+ channels or calcium leakage leads to further increases in intracellular Ca 2+ levels, which in turn enhances the release of the excitatory neurotransmitter glutamate, resulting in excitotoxic cell death