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Figure 4 Preclinical Studies Related to the Effects of Cannabinoids and Cannabinoid Receptor on Stroke Outcome Different preclinical studies demonstrated the effects of cannabinoids and cannabinoid receptors on stroke outcome, One of particular interest is the fact that cannabinoids not only decreased infarct volume following an ischemic stroke (both transient and permanent occlusion models), but also improved early and late functional outcome (England et al., 2015)