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In smokers volar forearm skin, we found increased epidermal differentiation, which may represent a compensatory mechanism induced as an adaptive response to environmental toxins such as PAHs present in cigarette smoke, or nicotine, both of which have the ability to stimulate keratinocyte differentiation

Steve Schroeder, distinguished professor of health and healthcare and director of the Smoking Cessation Leadership Center at the University of California San Francisco, told INSIDER

Monitoring and Support Programs : For those with extreme caffeine dependency, medical supervision, including regular check-ins with healthcare professionals, supports gradual reduction efforts and monitors health markers