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Acknowledgements This work was supported under grants from the National Natural Science Foundation of China (grant numbers: 22076104, 91943301, 21920102007, and 81970427), the International Collaboration Key Grant from the Chinese Academy of Sciences (grant number: 121311KYSB20190010), the Outstanding University Driven by Talents Program and Academic Promotion Program of Shandong First Medical University (grant number: 2020LJ002), and National Key R&D Program of China (grant number: 2021YFE0101500)

Impaired SPM biosynthesis and signaling contribute to sustained plaque macrophage activation, defective efferocytosis, and expansion of the necrotic core, whereas restoration of SPM pathways enhances apoptotic cell clearance and promotes a pro-resolving macrophage phenotype (61, 62, 106, 131)

Theranostic nanosystem mediating cascade catalytic reactions for effective immunotherapy of highly immunosuppressive and poorly penetrable pancreatic tumor

The water-soluble nature of B12 means several things for patients : the vitamin requires regular dietary intake to maintain optimal levels, it can be lost during food preparation (particularly with prolonged cooking or boiling), and therapeutic doses are generally considered safe as excess is eliminated through the kidneys, though the body's substantial hepatic storage also plays a role in B12 metabolism

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186 MDVs primarily fuse with multivesicular bodies, such as late endosomes and lysosomes, although a select few are secreted into the extracellular space via a process driven by OPA1 and Snx9