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10.1038/s41598-020-70309-2 55 HarveyA

Non-angiogenic tumours: rational for resistance to anti-angiogenic treatment

Analysis of candidate cis-regulatory elements (cCREs) has shown that some diabetes-associated variants reduce chromatin accessibility at binding sites for transcription factors such as HNF1A and HNF4A, thereby impairing maintenance of a functional phenotype (Wang et al., 2023)