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Most tobacco products, including e cigarettes, contain nicotine, a chemical that can harm the heart, brain and whole body. As with other addictive products, using a nicotine product builds tolerance, leading to more Smoking and the brain: What are the effects? What Happens When You Stop Smoking? Health effects of smoking tobacco Wikipedia Nicotine, tobacco smoking, and pain in orthopedic trauma settings: a conceptual framework for practice and research Archives of Orthopaedic and Trauma Surgery Springer Nature Link Adverse Health Effects of Smoking Cigarettes
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