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Recent drug discovery strategies are based on two criteria: first, compound structures that are distinct from bicalutamide and enzalutamide to avoid cross-resistance and, second, compounds that retain antagonist properties even for known AR mutant proteins that adopt agonist conformations when bound to current AR antagonists (also known as pan-antagonists)

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Further, AR45 protein interacts with membrane-associated G proteins Gq and Go

Por otra parte, antes del tratamiento con orlistat se produca un alza importante en los niveles de triglicridos durante la tarde, que es el tpico comportamiento de los pacientes resistentes a la insulina

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