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ATMs must handle lipids released from stressed or dying adipocytes, hepatic macrophages encounter fatty acids, oxidized lipoproteins, and inflammatory signals derived from the gut and injured hepatocytes, and plaque macrophages process modified LDL, cholesterol, apoptotic cells, and inflammatory lipid mediators

Excessive mitochondrial ROS (mtROS) production can suppress immunoglobulin production via T-cell-dependent antigens 20

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Once extracted, the protein free acidic sample can be stored at -20C for several months or indefinitely at -80C

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