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First, the Pro-Gly-Pro tail is enzymatically cleaved to release active metabolites, including Tuftsin-like fragments that retain GABAergic and immunomodulatory activity

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These compounds are often obtained through unregulated sources that may lack quality control standards

reconstituted solutions are not

Quiles, J

This implies that for the time period when patients are receiving these first-generation LAIs, they do prevent hospitalizations, but unfortunately patients are less likely to stay on these treatments and discontinue as a result of adverse events such as extrapyramidal symptoms [5]