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Myofibroblasts also have unique cell surface markers such as CD49e (alpha 5 integrin) [190], CD29 (beta 1 integrin) [191], and CD9 (tetraspanin glycoprotein) [192] are found on various subsets of myofibroblasts, and they could be leveraged in targeted antibody-drug conjugates while sparing quiescent fibroblasts

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TABLE 5 Pharmacokinetic parameters of BPC157 in dogs following intramuscular administration of doses ranging between 6 and 150 g/kg (mean SD, n = 6)