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Description

G., Shotton, D

TNF: tumor necrosis factor-alpha MASLD is a multifaceted spectrum of liver alterations linked to genetic, epigenetic, and environmental risk factors that affect lipid homeostasis, altering the generation, oxidation, and release of free fatty acids (FFA), cholesterol, triglycerides (TG), and bile acids (BAs)

While gene therapy is available for a small subset of patients with specific mutations, developing a therapeutic that broadly targets the cellular stresses that lead to cell death could address a major unmet need