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Abbreviations TME: Tumor microenvironment ROS: Reactive Oxygen species NK cells: Natural killer cells DCs: Dendritic cells GLS: Glutaminase -KG: -Ketoglutarate TCA: Tricarboxylic acid cycle HIF: Hypoxia-inducible factor LDHA: Lactate dehydrogenase A GSH: Glutathione NADPH: Nicotinamide adenine dinucleotide phosphate NF-B: Nuclear factor-kappa B IFN-: -Interferon CAFs: Cancer-associated fibroblasts PBTLs: Peripheral blood T lymphocytes SERCA: Sarcoplasmic reticulum Ca 2 + -ATPase Th1: CD4 + T helper 1 Th2: CD4 + T helper 2 Treg: Regulator T Th17: CD4 + T helper 17 SLC1A5: Solute carrier family 1 neutral amino acid transporter member 5 ASCT2: Alanine, serine, cysteine-preferring transporter 2 SLC7A5: Solute carrier family 7, member 5 SNAT: Sodium-coupled neutral amino acid transporter LPS: Lipopolysaccharide TAMs: Tumor-associated macrophages GS: Glutamine synthase HBP: Hexosamine biosynthetic pathway TANs: Tumor-associated neutrophils NETs: Neutrophil extracellular traps L-DON: 6-Diazo-5-oxo-L-norleucine AMPK: AMP kinase TILs: CD8 + tumor-infiltrating lymphocytes OXPHOS: Oxidative phosphorylation MDSCs: Myeloid-derived suppressor cells ECM: Extracellular matrix GFPT1: Glutamine-fructose aminotransferase 1 CTLs: Cytotoxic T lymphocytes CAR: Chimeric antigen receptor TNBC: Triple-negative breast cancer B7H3: B7 homology 3 References Hanahan D, Weinberg RA