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The percent of patients symptom-free of heartburn by day are shown in the Figures 4 and 5: Figure 4: Percent of Patients Symptom-Free of Heartburn by Day (Study 225) Figure 5: Percent of Patients Symptom-Free of Heartburn by Day (Study 226) In three European symptomatic GERD trials, NEXIUM 20 mg and 40 mg and omeprazole 20 mg were evaluated

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The final structures were validated using MolProbity 102 and the PDB validation server ( Residues with poor rotamer conformations and Ramachandran outliers were corrected in Coot

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In vitro studies showed that both recombinant E