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Simultaneously, inhibition of nitric oxide synthase and soluble guanylate cyclase mediates its vasoconstrictive properties

Mutation to a tyrosine of residue 220 within this helix was previously shown to affect the pK(a) of Tyr-9 at the active site, in the apo form of the enzyme, and it was proposed that an on-face hydrogen bond between Tyr-220 and Tyr-9 provided a means for affecting this pK(a)

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Safety Information: Read the label carefully before use Keep out of reach of children Keep the container tightly closed Do not exceed the recommended dosage Pregnant/lactating women and children with a medical condition should consult a physician before use Keep sealed in room temperature (1-30) Not Suitable For Breast feeder

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Autore F, Chiusolo P, Sor F, Giammarco S, Laurenti L, Innocenti I, et al