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A prominent example is the calcineurin inhibitor cyclosporine coadministration of berberine has been shown to markedly increase cyclosporine blood concentrations, risking toxicity

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Thus, based on the aforementioned potential pathological mechanisms, it is hypothesized that inhibiting NETs formation or promoting NETs degradation could potentially prevent the occurrence of ECMO-related acute kidney injury in the early stages

W literaturze naukowej zosta szerzej opisany w 1993 roku przez zesp Predraga Sikiria (m.in